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Titanium Dioxide

Titanium dioxide is a pure pharmaceutical grade naturally occurring mineral.  Titanium dioxide has a long history of safe use, it is recognized as being biologically inactive in the body, and is internationally recognized as being non-irritating and nontoxic.

We would like to assure you that the Scientific Advisory Board (SAB) members would never allow a questionable ingredient to be used in any GNLD product.  The members of the SAB continue to maintain a close watch on any research that might call into question the safety of any of the ingredients we use.  We are convinced that you can trust our products for you and your family because we trust them with ours.

WEBMASTER"S NOTE:  They say there haven't been any human trials.....They didn't check with me!  I have been taking GNLD products regularly for over 25 years and I have no physical complaints AT ALL (as of this writing, I am 61 years old).  If there were side-effects or dangers from Titanium Dioxide, I haven't felt them yet.  I guess I need say no more.

Titanium dioxide is the subject of new controversy, yet it is a substance as old as the earth itself.  It is one of the top fifty chemicals produced worldwide.  Titanium dioxide has a variety of uses, as it is odorless and absorbent.  This mineral can be found in many products, ranging from food to cosmetics.  It is a white, opaque and naturally occurring mineral found in two main forms:  rutile and anatase.  Both forms contain PURE titanium dioxide that is bound to impurities.  Titanium dioxide used in foods, cosmetics and supplements is processed to remove these impurities, leaving the pure, white pigment available for use.

Concern has arisen from studies that have pointed to titanium dioxide as a carcinogen and photocatalyst, thus creating fear in consumers.  But are these claims true?  What does the research on these allegations bear out?  Would we as consumers benefit from avoiding this mineral to preserve our long-term health?

A carcinogen is a substance that causes a cellular malfunction, causing the cell to become cancerous and thus potentially lethal to the surrounding tissue and ultimately the body as these rapidly growing mutated cells take over.  With the surge in cancer rates among all segments of the population, many people are attempting to reduce or eliminate their exposure to carcinogens.

Titanium dioxide is regarded as an inert, non-toxic substance by many regulatory bodies such as the MSDS (Material Safety Data Sheets) and others charged with the responsibility of safeguarding the health of occupational workers and public health.  The MSDS states that titanium dioxide can cause some lung fibrosis at FIFTY TIMES the nuisance dust defined by the US Department of Labor as 15 mg/m cubed (OSHA) or 10 mg/m cubed (ACGIH Threshold Limit Value).

The ACGIH states that titanium dioxide is “not classifiable as a human carcinogen”.  Symptoms of chronic overexposure to titanium dioxide in an industrial setting, according to the MSDS, include a “slight increase in lung tumour incidence in lab rats”.  It also states ’.  The NIOSH declares that at 5000 mg/m cubed there was slight lung fibrosis, concluding that this substance was carcinogenic in rats.  (Let it me noted that 5000 mg/m cubed is way over fifty times the nuisance dust loading level defined by the US Department of Labor.)

The NIOSH declaration of carcinogenicity in rats is based on a study by Lee, Trochimowicz & Reinhardt, “Pulmonary Response of Rats Exposed to Titanium Dioxide by Inhalation for Two Years” (1985).  The authors of this study found that rats chronically exposed to excessive dust loading of 250 mg/m cubed and impaired clearance mechanisms within the rat, for six hours per day, five days per week for two years, developed slight lung tumours.  They also noted that the biological relevance of this data to lung tumours in humans is negligible.

It is important to note that rats are known to be an extremely sensitive species for developing tumours in the lungs when overloaded with poorly soluble, low toxicity dust particles.  Rat lungs process particles very differently compared to larger mammals such as dogs, primates or humans (Warheit, 2004).  This sensitivity in the lungs has not been observed in other rodent species such as mice or hamsters (Warheit, 2004), therefore using the rat model to determine carcinogenicity of titanium dioxide in humans can be misleading, as extrapolation of species-specific data to humans is erroneous.

Many organizations and businesses have perpetuated this assessment of the carcinogenicity of titanium dioxide (ewg.org).  However, several studies and study reviews have been used to compile the safety disclaimers for the regulations on the permitted use of titanium dioxide.

One such study review took place in Rome, 1969 between the World Health Organization and the Food & Agriculture Organization of the United Nations.  Cross species analyses were performed and reviewed for possible toxicity of titanium dioxide.  The conference concluded that among the following species: rats, dogs, guinea pigs, rabbits, cats and human males, ingestion of titanium dioxide at varying diet percentages and over long periods of time did not cause absorption of this mineral.  Titanium dioxide particulates were not detected in the blood, liver, kidney or urine and no adverse effects were noted from its ingestion.  The U.S. Food & Drug Administration (2002) allows for its ingestion, external application including the eye area, and considers it a safe substance for public health.  Other epidemiological studies showed that workers exposed to titanium dioxide exhibited no statistically significant relationship between such exposure with lung cancer and respiratory disease, although some cases of pulmonary fibrosis did occur.  These studies were conducted in industrial settings where the increased exposure puts these individuals more at risk than the average person.

As with any health issue, relevant studies must be examined closely to reach balanced conclusions about its impact on our health and well-being.  Often, risk determinations are made without considering actual hazards and real-life exposures (Warheit, 2004).

References:
* Antczak, Cosmetics Unmasked.  Harper Collins; London:2001
* Blake, et.al.  “Application of the Photocatalytic Chemistry of TiO2 to Disinfection and the Killing of Cancer Cells”, Separation and Purification Methods; Vol 28 (1) 1999 p.1-50
* Churg, Gilks, Dai, UBC Dept. of Pathology.  Am J Physiol Lung Cell Mol Physiol.  Vol 277 Issue 5 L975-L982, 1999
* Dunford, et. al.  FEBS Letters 418, 87 1997
* Etcgroup.org
* Kamazawa, et.al.  “Effects of Titanium Ions and Particles of Neutrophil Function and Morphology”.  Biomaterials 2002 Sep 23 (17): 3757-64
* Powell, et. al.  GUT 38, 390 1996
* Warheit, David “Nanoparticles: Health Impacts?”.  Materials Today, Feb. 2004
* Witt, Stephen.  Director of Technological Support, N. American Refractories Co.

*** As set down by the Food and Drug Administration, vitamin supplement products cannot be advertised as intended to diagnose, treat, cure or prevent any disease. ***