The goals of treatment of depression include reducing the symptoms of depression and facilitating the patient's return to functioning at the level prior to the onset of illness. Usually the treatment of depression includes psychotherapy and the use of pharmacologic agents. The most commonly used medications for uncomplicated depression are the tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). If a patient is refactory to the actions of one agent, therapy is often switched to the other. Of the tricyclic antidepressants, amitriptyline and imipramine are the most extensively studied and used. All TCAs potentiate the activity of norepinephrine and serotonin by blocking their re-uptake. Because TCAs affect other receptor systems, anticholinergic, neurologic, and cardiovascular adverse events are frequently reported. SSRIs were developed from the perceived need for improved efficacy and adverse effects profile compared with traditional TCAs. Patients who fail to respond to TCAs often respond to an SSRI, and visa versa.
If a patient is unresponsive to either agent, others are considered, including buproprion, which blocks re-uptake of dopamine, mirtazapine, a tetracyclic antidepressant with mixed serotonin/norepinephrine effects, or a triazolopyridine (trazodone or nefazodone), which has a dual action as a serotonin antagonist and also a re-uptake inhibitor.
Monoamine oxidase inhibitors (phenelzine, tranylcypromine) are used in cases of atypical depression. Clinical features of atypical depression that predict preferential response to MAOIs include mood reactivity, irritability, hypersomnia, hyperphagia, psychomotor agitation, and hypersensitivity to rejection.
Mood disorders, depression, and anxiety are common illnesses in our society. Lost work time, family conflicts, personal strife, and other consequences of the disease can eventually lead to complete disruption of one's life. Depression and mood disorders have become increasingly recognized as common, yet under-diagnosed and under-treated conditions.
Foods that have been proven to help with Depression:
Dairy, turkey, soy, flaxseed, fish, and whole eggs products.
Nutrients that have been proven to help with Depression:
S-Adenosyl methionine (SAMe), 5-Hydrxytryptophan (5-HTP), Phenylalanie, Dehydroepiandrosterone (DHEA), Omega 3 Fatty Acids, Vitamin B6, Vitamin B12, Folic Acid, St. John's Wort, and Ginkgo.
S-Adenosyl methionine (SAMe) is one of the most studied non-drug antidepressants available today. SAMe is a naturally occurring substance synthesized in the body from the amino acid methionine. It is critical for the synthesis of neurotransmitters. The excitement surrounding SAMe's effectiveness as a natural antidepressant is balanced by the fact that it is a relatively costly supplemenet, if the therapeutic dosage is maintained.
5-Hydrxytryptophan (5-HTP) and tryptophan are the precursors for serotonin. Tryptophan is an essential amino acid that the body cannot manufacture. Tryptophan is converted into 5_HTP, which in turn is converted into serotonin. There is ample evidence that tryptophan depletion causes reduced synthesis of serotonin, which results in depression and other mood disorders.
Tryptophan is not available to the general public as a nutritional supplement. Without tryptophan on the market, 5-HTP has entered into the public's awareness as an effective and natural therapy for anxiety, depression and sleep disorders. Either substance can be used to enhance serotonin synthesis in the brain. It is now recognized that 5-HTP is more effective at elevating serotonin levels than tryptophan.
Phenylalanie and tyrosine are the precursosrs to the neurotransmitters dopamine, norepinephrine, and epinephrine, which all influence and regulate mental and emotional states. Tyrosine is synthesized from phenylalanine and this it is not an essential amino acid. No large well-controlled studies on tyrosine and depression have been conducted to date.
Dehydroepiandrosterone (DHEA) appears to be safe and without significant side effects, however, long-term human trials have not been conducted.
Exercises that have been proven to help with Depression:
The link between exercise and depression has been the focus of many scientific studies. This research repeatedly shows that exercise really does help depression. Exercise has been shown to be as effective or better in reducing depression symptoms as antidepressants, individual and group psychotherapy and cognitive therapy.
Basic Plan for Depression:
Stress 30, Beta-Zyme Digestive Enzymes,
Premium All-Purpose Protein, Salmon Oil Plus,
Omega III Concentrate, Acidophilus Plus, Enersine,
Feminine Herbal Formula, B Complex Threshold Control
***As set down by the Food and Drug Administration, vitamin supplement products cannot be advertised as intended to diagnose, treat, cure or prevent any disease.***